The 10th Takeda Science Foundation Symposium on PharmaSciences

as of December, 2019

January 24
09:20Opening Remarks
Shuh Narumiya   Kyoto University, Japan

Session 1 -Part 1-
General Introduction : Towards Human Biology

Chairpersons: Akira Sawa & Anissa Abi-Dargham

09:25S1-1 The Contribution of Genes and Environment to the Evolution of Psychosis
Raquel E. Gur
University of Pennsylvania, U. S. A.
09:55S1-2 An integrated view of Complex psychiatric phenotypes
Shigenobu Kanba
Kyushu University, Japan

Coffee Break (15 min.) 10:25-10:40

Session 1 -Part 2-
10:40S1-3 Charting mental disorders from childhood to midlife
Avshalom Caspi
Duke University, U. S. A.
11:10S1-4 Evidence synthesis: Present and future
Toshiaki A. Furukawa
Kyoto University, Japan

<Lunch> 11:40-12:20 (40 min.)

<Poster Session> (45 min. each)
12:20-13:05 / Odd Number
13:05-13:50 / Even Number

Session 2
Imaging & Computation

Chairpersons: Shigenobu Kanba & Raquel E. Gur

13:55S2-1 New insights into the topography and mechanisms of dopaminergic alterations in schizophrenia
Anissa Abi-Dargham
Stony Brook University, U. S. A.
14:25S2-2 Biological factors related to the onset of psychosis
Philip McGuire
King’s College London, U. K.
14:55S2-3 E/I-balance and gamma-band oscillations across
illness-stages in Schizophrenia: Using Magnetoencephalography to identify circuit dysfunctions and biomarkers
Peter J. Uhlhaas
Charite Universitätsmedizin Berlin, Germany
15:25S2-4 Salience account of delusion and hallucination
Jun Miyata
Kyoto University, Japan

Coffee Break (25 min.) 15:55-16:20

Session 3
Synaptic / Neural Circuit Mechanisms

Chairpersons: Tomoyuki Furuyashiki & Jonathan Kipnis

16:20S3-1 Computational neuroscience approach to mental disorders
Mitsuo Kawato
Advanced Telecommunications Research Institute International (ATR), Japan
16:50S3-2 Multi-scale Understanding of Synaptic Pathology of Psychiatric Disorders
Akiko Hayashi-Takagi
RIKEN Center for Brain Science, Japan
17:20S3-3 Neural Circuit Mechanisms of Emotional and Social Processing
Kay M. Tye
The Salk Institute for Biological Studies, U. S. A.
17:50S3-4 Innate fear odors elicit a physiological crisis mode that promotes survival in life-threatening situations
Ko Kobayakawa
Kansai Medical University, Japan

Welcome Reception 18:35-20:20


January 25
Session 4
Inflammation & Mental Illness

Chairpersons: Akiko Hayashi-Takagi & John H. Krystal

09:00S4-1 Meningeal immunity and lymphatics in CNS function and dysfunction
Jonathan Kipnis
University of Virginia, U. S. A.
09:30S4-2 Psychological Stress and Prolonged Anxiety: Key interactions between Microglia, Monocytes, and Endothelial cells
Jonathan Godbout
The Ohio State University, U. S. A.
10:00S4-3 Stress and innate immune responses in the brain
Tomoyuki Furuyashiki
Kobe University, Japan
10:30S4-4 Inflammation and depression
Edward T. Bullmore
University of Cambridge, U. K.

Coffee Break (25 min.) 11:00-11:25

Session 5
Disease Trajectory

Chairperson: Avshalom Caspi

11:25S5-1 Looking for critical mediators in major mental illnesses: early detection and intervention
Akira Sawa
Johns Hopkins Hospital, U. S. A.
11:55S5-2 Next Generation Therapeutics of Anxiety and PTSD: neural circuitry & cell-type specific approaches to amygdala functioning and threat processing
Kerry J. Ressler
McLean Hospital, U. S. A.

<Speaker's Photo Session> 12:25-12:35 (10 min.)

<Lunch>12:35-13:20 (45 min.)

<Poster Session -Free Discussion->13:20-14:05 (45 min.)

Session 6 -Part 1-

Chairpersons: Shuh Narumiya & Edward T. Bullmore

14:05S6-1 Rapid-Acting Antidepressants: New treatments, new hope, and new insights into the brain
John H. Krystal
Yale University school of Medicine, U. S. A.
14:35S6-2 Quo Vadis Ketamine Enantiomers?
Kenji Hashimoto
Chiba University, Japan

Coffee Break (20 min.) 15:05-15:25

Session 6 -Part 2-
15:25S6-3 Prefrontal cortical synaptic remodeling in depression-related behavioral states
Conor Liston
Weill Cornell Medicine, U. S. A.
15:55S6-4 Development and Stress: Exploring Novel Drugs Targeting Inflamed Brain for Psychiatric Disorders
Atsushi Kamiya
Johns Hopkins University, U. S. A.
16:25S6-5 Modeling Neuropsychiatric Disorders using Human Stem Cells
Fred H. Gage
The Salk Institute for Biological Studies, U. S. A.
16:55Award Ceremony
Kay M. Tye  The Salk Institute for Biological Studies, U. S. A.
Raquel E. Gur  University of Pennsylvania, U. S. A.
17:05Closing Remarks
Akira Sawa  Johns Hopkins Hospital, U. S. A.